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Genomic-epidemiological analysis of 15 million SARS-CoV-2 genomes reveals accelerated fitness gain of JN.1 lineage.

Virologica Sinica - 1 Apr 2026

Lei Zhong-Yi, Jin Qian-Tong, Zhang Xiao-Min, Bo Xiao-Chen, Ren Zi-Lin, Tong Yi-Gang, Ni Ming

Abstract excerpt

The evolution of SARS-CoV-2 has been driven by successive globally circulating waves, including the Alpha and Delta lineages, early Omicron (BA.1-BA.5), XBB, and the recently dominant JN.1 lineages. Although the marked advantage in fitness of early Omicron over Delta lineages has been recognized, there is a lack of systematic evaluation of SARS-CoV-2 fitness across 2020 to 2025. Here, we analyzed 15.23 million...

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Identifiers

PMID: 41962740
DOI: 10.1016/j.virs.2026.03.015
PMCID: PMC13215966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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