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Article

A Broad Overview of Signaling in Ph-Negative Classic Myeloproliferative Neoplasms

26 Feb 2021

Abstract excerpt

-negative myeloproliferative neoplasms (polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF)) are infrequent blood cancers characterized by signaling aberrations. Shortly after the discovery of the somatic mutations in JAK2, MPL, and CALR that cause these diseases, researchers extensively studied the aberrant functions of their mutant products. In all three cases, the main...

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PMID: 33652860
DOI: 10.3390/cancers13050984

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