Article
Analytical approaches to the diagnosis and treatment of aging and aging-related disease: redox status and proteomics.
Free radical research - 1 May 2015
Calabrese V, Dattilo S, Petralia A, Parenti R, Pennisi M, Koverech G, Calabrese V, Graziano A, Monte I, Maiolino L, Ferreri T, Calabrese E J
Abstract excerpt
Basal levels of oxidants are indispensible for redox signaling to produce adaptive cellular responses such as vitagenes linked to cell survival; however, at higher levels, they are detrimental to cells, contributing to aging and to the pathogenesis of numerous age-related diseases. Aging is a complex systemic process and the major gap in aging research reminds the insufficient knowledge about pathways shifting...
Topics
- Age Factors
- Aging
- Animals
- Biomarkers
- Disease Susceptibility
- Glutathione
- Humans
- Lipid Peroxidation
- Oxidation-Reduction
- Oxidative Stress
- Phenotype
