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Article

Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants.

Genome medicine - 20 May 2022

Chen Rui, Yang Zhihui, Liu Jiewei, Cai Xin, Huo Yongxia, Zhang Zhijun, Li Ming, Chang Hong, Luo Xiong-Jian

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging. METHODS: We first integrated chromatin immunoprecipitation sequencing (ChIP-Seq) data from human brain tissues (or neuronal cell lines) and position weight...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35590387
DOI: 10.1186/s13073-022-01057-3
PMCID: PMC9121601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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