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Article

Genetic associations between bipolar disorder and brain structural phenotypes.

Cerebral cortex (New York, N.Y. : 1991) - 24 May 2023

Shang Meng-Yuan, Zhang Chu-Yi, Wu Yong, Wang Lu, Wang Chuang, Li Ming

Abstract excerpt

Patients with bipolar disorder (BD) and their first-degree relatives exhibit alterations in brain volume and cortical structure, whereas the underlying genetic mechanisms remain unclear. In this study, based on the published genome-wide association studies (GWAS), the extent of polygenic overlap between BD and 15 brain structural phenotypes was investigated using linkage disequilibrium score regression and MiXeR...

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PMID: 36734292
DOI: 10.1093/cercor/bhad014

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