Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rodent models in Down syndrome research: impact and future opportunities.

Disease models & mechanisms - 1 Oct 2017

Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique

Abstract excerpt

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse models with Down-syndrome-related features has been developed to understand this complex human chromosomal disorder. These mouse models have been important for determining genotype-phenotype relationships and identification of dosage-sensitive genes involved in the pathophysiology of the condition, and in exploring the impact of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Cognition

Share to Down Syndrome

Share to Gene Dosage

Share to Mice, Transgenic

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 28993310
DOI: 10.1242/dmm.029728
PMCID: PMC5665454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rodent models in Down syndrome research: impact and future opportunities.PMID 28993310Read ↗

The power of comparative and developmental studies for mouse models of Down syndrome.Semantic proximity Read ↗

[Relevance of animal models in the study of human pathologies: a mouse model of Down syndrome].Semantic proximity Read ↗

A new Down syndrome rat model races forward.Semantic proximity Read ↗

Mouse-based genetic modeling and analysis of Down syndromeSemantic proximity Read ↗

Models for Down syndrome: chromosome 21-specific genes in mice.Semantic proximity Read ↗

Molecular genetic analysis of Down syndrome.Semantic proximity Read ↗

Down syndrome mouse models are looking up.Semantic proximity Read ↗

Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for TherapeuticsSemantic proximity Read ↗

Mouse Models for Down Syndrome-Associated Developmental Cognitive DisabilitiesSemantic proximity Read ↗

All Creatures Great and Small: New Approaches for Understanding Down Syndrome GeneticsSemantic proximity Read ↗

Mouse models of Down syndrome: gene content and consequencesSemantic proximity Read ↗

Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.