Article

Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations

2020-04-14

Abstract excerpt

The entry of SARS-CoV-2 into host cells is dependent upon angiotensin-converting enzyme 2 (ACE2), which serves as a functional attachment receptor for the viral spike glycoprotein, and the serine protease TMPRSS2 which allows fusion of the viral and host cell membranes. We devised a quantitative measure to estimate genetic determinants of ACE2 and TMPRSS2 expression and applied this measure to >2,500 individuals...

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Literature Corpus work: 53b0c79a-7193-59bf-9306-82ff4b6a7d45
DOI: 10.1101/2020.04.06.027698

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