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Article

Genetic origin of patients having spastic paraplegia with or without other neurologic manifestations.

BMC neurology - 16 May 2022

Chen Jiannan, Zhao Zhe, Shen Hongrui, Bing Qi, Li Nan, Guo Xuan, Hu Jing

Abstract excerpt

BACKGROUND: Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases characterized by lower-limb spastic paraplegia with highly genetic and clinical heterogeneity. However, the clinical sign of spastic paraplegia can also be seen in a variety of hereditary neurologic diseases with bilateral corticospinal tract impairment. The purpose of this study is to identify the disease spectrum of spastic...

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Source

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Identifiers

PMID: 35578252
DOI: 10.1186/s12883-022-02708-z
PMCID: PMC9109329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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