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Constitutional and acquired genetic variants in ARID5B in pediatric B-cell precursor acute lymphoblastic leukemia.

Genes, chromosomes & cancer - 1 May 2024

Ragnarsson Charlotte, Yang Minjun, Moura-Castro Larissa Helena, Aydın Efe, Gunnarsson Rebeqa, Olsson-Arvidsson Linda, Lilljebjörn Henrik, Fioretos Thoas, Duployez Nicolas, Zaliova Marketa, Zuna Jan, Castor Anders, Johansson Bertil, Paulsson Kajsa

Abstract excerpt

Constitutional polymorphisms in ARID5B are associated with an increased risk of developing high hyperdiploid (HeH; 51-67 chromosomes) pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL). Here, we investigated constitutional and somatic ARID5B variants in 1335 BCP ALL cases from five different cohorts, with a particular focus on HeH cases. In 353 HeH ALL that were heterozygous for risk alleles and...

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PMID: 38738968
DOI: 10.1002/gcc.23242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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