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Article

Comparative genomic analysis of Mycobacterium tuberculosis Beijing-like strains revealed specific genetic variations associated with virulence and drug resistance.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2017

Rodríguez-Castillo Juan Germán, Pino Camilo, Niño Luis Fernando, Rozo Juan Carlos, Llerena-Polo Claudia, Parra-López Carlos A, Tauch Andreas, Murcia-Aranguren Martha Isabel

Abstract excerpt

Isolates of the Mycobacterium tuberculosis lineage 2/East-Asian are considered one of the most successful strains due to their increased pathogenicity, hyper-virulence associated with drug resistance, and high transmission. Recent studies in Colombia have shown that the Beijing-like genotype is associated with multidrug-resistance and high prevalence in the southwest of the country, but the genetic basis of its...

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PMID: 28734764
DOI: 10.1016/j.meegid.2017.07.022

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