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Article

Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster.

BMC infectious diseases - 23 Jun 2023

Mokrousov Igor, Vyazovaya Anna, Shitikov Egor, Badleeva Maria, Belopolskaya Olesya, Bespiatykh Dmitry, Gerasimova Alena, Ioannidis Panayotis, Jiao Weiwei, Khromova Polina, Masharsky Aleksey, Naizabayeva Dinara, Papaventsis Dimitrios, Pasechnik Oksana, Perdigão João, Rastogi Nalin, Shen Adong, Sinkov Viacheslav, Skiba Yuriy, Solovieva Natalia, Tafaj Silva, Valcheva Violeta, Kostyukova Irina, Zhdanova Svetlana, Zhuravlev Viacheslav, Ogarkov Oleg

Abstract excerpt

BACKGROUND: . The Mycobacterium tuberculosis Beijing genotype is globally spread lineage with important medical properties that however vary among its subtypes. M. tuberculosis Beijing 14717-15-cluster was recently discovered as both multidrug-resistant, hypervirulent, and highly-lethal strain circulating in the Far Eastern region of Russia. Here, we aimed to analyze its pathogenomic features and phylogeographic...

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PMID: 37353765
DOI: 10.1186/s12879-023-08413-7
PMCID: PMC10288800

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