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Article

Dysbiotic Lesional Microbiome With Filaggrin Missense Variants Associate With Atopic Dermatitis in India.

Frontiers in cellular and infection microbiology - 1 Jan 2020

Nath Shankha, Kumari Naina, Bandyopadhyay Debabrata, Sinha Neloy, Majumder Partha P, Mitra Rupak, Mukherjee Souvik

Abstract excerpt

Background: Atopic Dermatitis (AD) has been associated with the loss of function (LoF) mutations in Filaggrin (FLG) gene and increase in relative abundance of specific microbes in the lesional skin, predominantly in Caucasians. Our study aims to determine, in Indian AD patients, (a) the prevalence of FLG LoF and missense mutations, and (b) the nature and extent of dysbiosis and altered microbial pathways with and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33282748
DOI: 10.3389/fcimb.2020.570423
PMCID: PMC7705349

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