A double point mutation of SOD1 targeting net charge promotes aggregation under destabilizing conditions: Correlation of charge distribution and ALS-provoking mutation.

doi:10.1016/j.bbagen.2023.130325

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Article

A double point mutation of SOD1 targeting net charge promotes aggregation under destabilizing conditions: Correlation of charge distribution and ALS-provoking mutation.

Biochimica et biophysica acta. General subjects - 1 May 2023

Mavadat Elaheh, Seyedalipour Bagher, Hosseinkhani Saman

Abstract excerpt

A progressive neurodegenerative illness such as amyotrophic lateral sclerosis (ALS) is characterized by the misfolding and aggregation of human CuZn superoxide dismutase (hSOD1) into amyloid aggregates. Thus, designing strategies for the choice of WT-SOD1 and double mutant (G12D/G138E) with an increased net negative charge can be a good idea to elucidate the pathological mechanism of SOD1 in ALS under some...

Topics

Humans
Superoxide Dismutase-1
Superoxide Dismutase
Amyotrophic Lateral Sclerosis
Point Mutation
Mutation
Amyloid
Amyloidogenic Proteins

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Identifiers

PMID: 36791828
DOI: 10.1016/j.bbagen.2023.130325

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