Article
"Stemness" genomics law governs clinical behavior of human cancer: implications for decision making in disease management.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jun 2008
Glinsky Gennadi V
Abstract excerpt
One of the most significant accomplishments of translational oncogenomics is a realistic promise of efficient diagnostic tests that would facilitate implementation of the concept of individualized cancer therapies. Recent discovery of the BMI1 pathway rule indicates that gene expression signatures (GESs) associated with the "stemness" state of a cell might be informative as molecular predictors of cancer therapy...
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