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Article

Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes.

Nature medicine - 1 May 2022

Nair Anand Thakarakkattil Narayanan, Wesolowska-Andersen Agata, Brorsson Caroline, Rajendrakumar Aravind Lathika, Hapca Simona, Gan Sushrima, Dawed Adem Y, Donnelly Louise A, McCrimmon Rory, Doney Alex S F, Palmer Colin N A, Mohan Viswanathan, Anjana Ranjit M, Hattersley Andrew T, Dennis John M, Pearson Ewan R

Abstract excerpt

Type 2 diabetes (T2D) is a complex chronic disease characterized by considerable phenotypic heterogeneity. In this study, we applied a reverse graph embedding method to routinely collected data from 23,137 Scottish patients with newly diagnosed diabetes to visualize this heterogeneity and used partitioned diabetes polygenic risk scores to gain insight into the underlying biological processes. Overlaying risk of...

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Share to Diabetes and associated disorders
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Associations and Epidemiology

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Identifiers

PMID: 35534565
DOI: 10.1038/s41591-022-01790-7

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