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Article

Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern.

Journal of molecular cell biology - 26 Aug 2024

Frasson Ilaria, Diamante Linda, Zangrossi Manuela, Carbognin Elena, Pietà Anna Dalla, Penna Alessandro, Rosato Antonio, Verin Ranieri, Torrigiani Filippo, Salata Cristiano, Dizanzo Marìa Paula, Vaccaro Lorenzo, Cacchiarelli Davide, Richter Sara N, Montagner Marco, Martello Graziano

Abstract excerpt

The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants, some of which are resistant to vaccines and drugs targeting viral elements. Targeting host dependency factors, e.g. cellular proteins required for viral replication, would help prevent the development of resistance. However, it remains unclear whether different SARS-CoV-2 variants induce conserved cellular responses and exploit the...

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Identifiers

PMID: 38305139
DOI: 10.1093/jmcb/mjae004
PMCID: PMC11411213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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