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Functional Antagonism between High Temperature Requirement Protein A (HtrA) Family Members Regulates Trophoblast Invasion

8 Jul 2014

Abstract excerpt

Human trophoblast invasion of decidualized endometrium is essential for placentation and is tightly regulated and involves trophoblast-decidual cell interaction. High temperature requirement A4 (HtrA4) is a secreted serine protease highly expressed in the invasive extravillous trophoblasts that invade decidua. In contrast, both HtrA1 and HtrA3 have been shown to inhibit trophoblast invasion. Here we provide...

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PMID: 25002585
DOI: 10.1074/jbc.m114.576744

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Related research

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Functional Antagonism between High Temperature Requirement Protein A (HtrA) Family Members Regulates Trophoblast InvasionPMID 25002585Read ↗

Distinct expression and localization of serine protease HtrA1 in human endometrium and first‐trimester placentaSemantic proximity Read ↗

Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblastsSemantic proximity Read ↗

Decidual HtrA3 negatively regulates trophoblast invasion during human placentation.Semantic proximity Read ↗

High-Temperature Requirement Protein A4 (HtrA4) Suppresses the Fusogenic Activity of Syncytin-1 and Promotes Trophoblast InvasionSemantic proximity Read ↗

Serine Peptidase HTRA3 Is Closely Associated with Human Placental Development and Is Elevated in Pregnancy Serum1Semantic proximity Read ↗

Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functionsSemantic proximity Read ↗

Overview of Human HtrA Family Proteases and Their Distinctive Physiological Roles and Unique Involvement in Diseases, Especially Cancer and Pregnancy ComplicationsSemantic proximity Read ↗

Interplay between HTRA1 and classical signalling pathways in organogenesis and diseasesSemantic proximity Read ↗

Abnormal development of placenta in HtrA1-deficient mice.Semantic proximity Read ↗

Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial DysfunctionSemantic proximity Read ↗

Inhibition of HTRA3 stimulates trophoblast invasion during human placental developmentSemantic proximity Read ↗

HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4Semantic proximity Read ↗

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