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Article

A Local Genetic Correlation Analysis Provides Biological Insights Into the Shared Genetic Architecture of Psychiatric and Substance Use Phenotypes.

Biological psychiatry - 1 Oct 2022

Gerring Zachary F, Thorp Jackson G, Gamazon Eric R, Derks Eske M

Abstract excerpt

BACKGROUND: Global genetic correlation analysis has provided valuable insight into the shared genetic basis between psychiatric and substance use disorders. However, little is known about which regions disproportionately contribute to the global correlation. METHODS: We used Local Analysis of [co]Variant Annotation to calculate bivariate local genetic correlations across 2495 approximately equal-sized,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35525699
DOI: 10.1016/j.biopsych.2022.03.001
PMCID: PMC11034779

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