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Article

Engineering of Bacillus subtilis for enhanced total synthesis of folic acid.

Applied and environmental microbiology - 1 Nov 2005

Zhu T, Pan Z, Domagalski N, Koepsel R, Ataai M M, Domach M M

Abstract excerpt

We investigated whether the yield of the B vitamin folic acid could be elevated in Bacillus subtilis. Strategies for increasing the folic acid yield were investigated by employing computer-aided flux analysis and mutation. Controlling the activity of the enzyme pyruvate kinase by placing it under inducible control was one strategy devised to elevate yield while insuring that a rapid growth rate results. Other...

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Identifiers

PMID: 16269750
DOI: 10.1128/AEM.71.11.7122-7129.2005
PMCID: PMC1287646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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