Article
Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors.
Virology journal - 14 Nov 2017
Meixenberger Karolin, Yousef Kaveh Pouran, Smith Maureen Rebecca, Somogyi Sybille, Fiedler Stefan, Bartmeyer Barbara, Hamouda Osamah, Bannert Norbert, von Kleist Max, Kücherer Claudia
Abstract excerpt
BACKGROUND: Detailed knowledge of the evolutionary potential of polymorphic sites in a viral protein is important for understanding the development of drug resistance in the presence of an inhibitor. We therefore set out to analyse the molecular evolution of the HIV-1 subtype B integrase at the inter-patient level in Germany during a 20-year period prior to the first introduction of integrase strand inhibitors...
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