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Article

Implications of HIV-1 M group polymorphisms on integrase inhibitor efficacy and resistance: genetic and structural in silico analyses.

Biochemistry - 13 Jan 2009

Loizidou Eriketi Z, Kousiappa Ioanna, Zeinalipour-Yazdi Constantinos D, Van de Vijver David A M C, Kostrikis Leondios G

Abstract excerpt

The extensive polymorphisms among HIV-1 subtypes have been implicated in drug resistance development. Integrase inhibitors represent the latest addition to the treatment of HIV-1, and their efficacy and resistance patterns among M group strains are currently under investigation. This study analyzed the intersubtype variation within 108 integrase sequences from seven subtypes. The residues associated with...

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Identifiers

PMID: 19090674
DOI: 10.1021/bi8019349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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