Article
HIP1R and vimentin immunohistochemistry predict 1p/19q status in IDH-mutant glioma.
Neuro-oncology - 1 Dec 2022
Felix Marius, Friedel Dennis, Jayavelu Ashok Kumar, Filipski Katharina, Reinhardt Annekathrin, Warnken Uwe, Stichel Damian, Schrimpf Daniel, Korshunov Andrey, Wang Yueting, Kessler Tobias, Etminan Nima, Unterberg Andreas, Herold-Mende Christel, Heikaus Laura, Sahm Felix, Wick Wolfgang, Harter Patrick N, von Deimling Andreas, Reuss David E
Abstract excerpt
BACKGROUND: IDH-mutant gliomas are separate based on the codeletion of the chromosomal arms 1p and 19q into oligodendrogliomas IDH-mutant 1p/19q-codeleted and astrocytomas IDH-mutant. While nuclear loss of ATRX expression excludes 1p/19q codeletion, its limited sensitivity prohibits to conclude on 1p/19q status in tumors with retained nuclear ATRX expression. METHODS: Employing mass spectrometry based proteomic...
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