Next-Generation Sequencing Panel for 1p/19q Codeletion and IDH1-IDH2 Mutational Analysis Uncovers Mistaken Overdiagnoses of 1p/19q Codeletion by FISH.

doi:10.1016/j.jmoldx.2021.06.004

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Article

Next-Generation Sequencing Panel for 1p/19q Codeletion and IDH1-IDH2 Mutational Analysis Uncovers Mistaken Overdiagnoses of 1p/19q Codeletion by FISH.

The Journal of molecular diagnostics : JMD - 1 Sept 2021

de Biase Dario, Acquaviva Giorgia, Visani Michela, Marucci Gianluca, De Leo Antonio, Maloberti Thais, Sanza Viviana, Di Oto Enrico, Franceschi Enrico, Mura Antonella, Ragazzi Moira, Serra Silvia, Froio Elisabetta, Bisagni Alessandra, Brandes Alba A, Pession Annalisa, Tallini Giovanni

Abstract excerpt

The 1p/19q codeletion is the result of a translocation between chromosome 1 (Chr1p) and chromosome 19 (Chr19q) with the loss of derivative (1;19)(p10;q10) chromosome. The 1p/19q codeletion has predictive and prognostic significance, and it is essential for the classification of gliomas. In routine practice, the fluorescence in situ hybridization (FISH) diagnosis of 1p/19q codeletion is sometimes unexpected. This...

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PMID: 34186176
DOI: 10.1016/j.jmoldx.2021.06.004

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