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Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

4 May 2022

Abstract excerpt

Interferon restricts SARS-CoV-2 replication in cell culture, but only a handful of Interferon Stimulated Genes with antiviral activity against SARS-CoV-2 have been identified. Here, we describe a functional CRISPR/Cas9 screen aiming at identifying SARS-CoV-2 restriction factors. We identify DAXX, a scaffold protein residing in PML nuclear bodies known to limit the replication of DNA viruses and retroviruses, as a...

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PMID: 35508460
DOI: 10.1038/s41467-022-30134-9

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