Massive tramadol ingestion resulting in fatal brain injury - a pharmacokinetic study with discussion on the involved mechanisms of toxicity.

doi:10.1080/15563650.2022.2071286

Article

Massive tramadol ingestion resulting in fatal brain injury - a pharmacokinetic study with discussion on the involved mechanisms of toxicity.

Clinical toxicology (Philadelphia, Pa.) - 1 Sept 2022

Puszkiel Alicja, Malissin Isabelle, Cisternino Salvatore, Pallet Nicolas, Declèves Xavier, Mégarbane Bruno

Abstract excerpt

BACKGROUND: Tramadol-attributed toxicity may involve opioid-like, serotoninergic, and noradrenergic mechanisms. We investigated the mechanisms of toxicity in a massive tramadol ingestion case by examining serial clinical, imaging, electroencephalography, pharmacokinetics, and genotyping data. CASE REPORT: A 32-year-old female who presumably ingested 9000 mg sustained-release tramadol was found comatose without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Massive tramadol ingestion resulting in fatal brain injury - a pharmacokinetic study with discussion on the involved mechanisms of toxicity.

Abstract excerpt

Topics

Related research