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Article

Rational testing for gene fusion in colorectal cancer: MSI and RAS-BRAF wild-type metastatic colorectal cancer as target population for systematic screening.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2022

Delaye Matthieu, Ibadioune Sabrina, Julié Catherine, Marin Cristi, Peschaud Frédérique, Lupinacci Renato, Vacher Sophie, Ahmanache Ladidi, Antonio Samantha, Schnitzler Anne, Buecher Bruno, Mariani Pascale, Allory Yves, Grati Olfa T, Emile Jean F, Neuzillet Cindy, Bièche Ivan

Abstract excerpt

Gene fusions provide access to new therapeutic opportunities for patients treated for a colorectal cancer (CRC). However, they do not excess 1% of patients. A better identification of patients in whom gene fusions are highly prevalent is a major issue in a therapeutic and medico-economics perspective. This study assesses the rates of gene fusions in CRC patients with MSI/RAS-BRAFWT in our routine practice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35598360
DOI: 10.1016/j.ejca.2022.04.024

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