Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare case of leptomeningeal small lymphocytic lymphoma with TP53 mutation detected by deep next-generation sequencing.

Leukemia & lymphoma - 1 Oct 2022

Evans Mark G, Shestakova Anna, Haghighi Nahideh, Zhao Xiaohui, Nardi Valentina, Pinter-Brown Lauren C, Rezk Sherif A

Abstract excerpt

Involvement of the central nervous system (CNS) is an exceedingly rare presentation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), with no consensus on the optimal therapy. Here we describe a 71-year-old man with a skull-base leptomeningeal mass consistent with SLL on biopsy. Malignant cells were observed in the cerebrospinal fluid (CSF), but not in the peripheral blood, bone marrow, or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Methotrexate

Share to Mutation

Share to Rituximab

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 35503707
DOI: 10.1080/10428194.2022.2070911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare case of leptomeningeal small lymphocytic lymphoma with TP53 mutation detected by deep next-generation sequencing.PMID 35503707Read ↗

Diagnostic and Therapeutic Updates in Leptomeningeal Disease.Semantic proximity Read ↗

Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Comparison of the Diagnostic Significance of CSF Metagenomic Next-generation Sequencing Copy Number Variation Analysis and Cytology in Leptomeningeal MalignancySemantic proximity Read ↗

Next Generation Sequencing in the Management of Leptomeningeal Metastases of Non-Small Cell Lung Cancer: A Case Report and Literature Review.Semantic proximity Read ↗

The early recognition and diagnosis of neoplastic meningitis.Semantic proximity Read ↗

Low-burden TP53 mutations represent frequent genetic events in CLL with an increased risk for treatment initiation.Semantic proximity Read ↗

Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation.Semantic proximity Read ↗

Molecular Analysis of Liquid Vitreous Biopsy Reveals Occult Lymphoma Following Cytology-Negative Biopsies of the Brain and Vitreous.Semantic proximity Read ↗

An ultra-deep sequencing strategy to detect sub-clonal TP53 mutations in presentation chronic lymphocytic leukaemia cases using multiple polymerases.Semantic proximity Read ↗

Case Report: Identification of Potential Prognosis-Related TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next Generation Sequencing: Two Cases.Semantic proximity Read ↗

Diagnosis of leptomeningeal metastasis through identification of circulating tumor cells in cerebrospinal fluid using the TargetSelector™ assaySemantic proximity Read ↗

Leptomeningeal metastases of solid cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.