Article
Next Generation Sequencing in the Management of Leptomeningeal Metastases of Non-Small Cell Lung Cancer: A Case Report and Literature Review.
Recent patents on anti-cancer drug discovery - 1 Jan 2021
Li Shuo, Ke Linping, Meng Xue, Zhou Haiyan, Zhang Xiqin, Wu Huaguo, Yu Jinming, Zhang Hui
Abstract excerpt
BACKGROUND: Diagnosis of Leptomeningeal Metastases (LM) from Non-Small Cell Lung Cancer (NSCLC) is usually based on clinical symptoms, Cerebral-Spinal Fluid (CSF) cytology, and neuro-imaging. However, early diagnosis of LM in NSCLC is challenging due to the low sensitivity of these approaches. The Next-Generation Sequencing (NGS) using CSF could help improve the diagnosis of LM and guide its treatment options....
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