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Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation.

Investigative ophthalmology & visual science - 1 Nov 2023

Kwak Jay Jiyong, Lee Kwang Seob, Lee Junwon, Kim Yong Joon, Choi Eun Young, Byeon Suk Ho, Chang Won Seok, Kim Yu Ri, Kim Jin Seok, Shin Saeam, Lee Seung-Tae, Kim Sung Soo, Lee Christopher Seungkyu

Abstract excerpt

Purpose: To determine the diagnostic potential of next-generation sequencing (NGS) in vitreous samples, analyze genotype-phenotype characteristics, and compare NGS of matched vitreous and brain samples in patients with associated central nervous system lymphoma (CNSL). Methods: A total of 32 patients suspected of vitreoretinal lymphoma (VRL) who underwent diagnostic vitrectomy and NGS were included in this...

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PMID: 37975847
DOI: 10.1167/iovs.64.14.27
PMCID: PMC10664732

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