Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder.

doi:10.1016/j.schres.2011.04.007

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Article

Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder.

Schizophrenia research - 1 Jul 2011

Abdolmaleky Hamid Mostafavi, Yaqubi Sahab, Papageorgis Panagiotis, Lambert Arthur W, Ozturk Sait, Sivaraman Vadivelu, Thiagalingam Sam

Abstract excerpt

INTRODUCTION: HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. However, evidence for the role of HTR2A polymorphism(s) in schizophrenia (SCZ) and bipolar...

Topics

Bipolar Disorder
Cell Adhesion Molecules, Neuronal
Chi-Square Distribution
Cytosine
DNA Methylation
Extracellular Matrix Proteins
Frontal Lobe
Gene Frequency
Genotype
Guanine
Humans
Nerve Tissue Proteins
Polymorphism, Genetic
Promoter Regions, Genetic
Receptor, Serotonin, 5-HT2A
Receptors, Dopamine
Reelin Protein
Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 21550210
DOI: 10.1016/j.schres.2011.04.007

Genes

HTR2A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-21550210-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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