Article
Dissecting and analyzing the Subclonal Mutations Associated with Poor Prognosis in Diffuse Glioma.
BioMed research international - 1 Jan 2022
Bai Ming, Wang Xiaolong, Zhang Huixue, Wang Jianjian, Lyaysan Gaysina, Xu Si, Tian Kuo, Wang Tianfeng, Li Jie, Wang Na, Lu Xiaoyu, Zhang Xiaoming, Wang Lihua
Abstract excerpt
The prognostic and therapeutic implications in diffuse gliomas are still challenging. In this study, we first performed an integrative framework to infer the clonal status of mutations in glioblastomas (GBMs) and low-grade gliomas (LGGs) by using exome sequencing data from TCGA and observed both clonal and subclonal mutations for most mutant genes. Based on the clonal status of a given gene, we systematically...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.