Article
Phage resistance mutation triggered by OmpC deficiency in Klebsiella pneumoniae induced limited fitness costs.
Microbial pathogenesis - 1 Jun 2022
Cai Ruopeng, Deng Hewen, Song Jinming, Zhang Lei, Zhao Rihong, Guo Zhimin, Zhang Xinxin, Zhang Hao, Tian Tian, Ji Yalu, Shi Kun, Li Jianming, Diao Naichao, Han Wenyu, Gu Jingmin, Du Rui
Abstract excerpt
Outer membrane proteins (OMPs) play an important role in bacterial fitness costs. Derived from the interaction between Klebsiella pneumoniae K7 and phage GH-K3, K7RB is an outer membrane porin-deficient phage-resistant mutant strain triggered by ompC712 deletion, exhibits expression inhibition of OmpC, OmpN, KPN_02430 and OmpF, but its fitness costs and regulatory mechanism remains unknown. In this study,...
Topics
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Bacteriophages
- Klebsiella pneumoniae
- Mutation
- Porins