Article
A Smooth-Type, Phage-Resistant Klebsiella pneumoniae Mutant Strain Reveals that OmpC Is Indispensable for Infection by Phage GH-K3.
Applied and environmental microbiology - 1 Nov 2018
Cai Ruopeng, Wu Mei, Zhang Hao, Zhang Yufeng, Cheng Mengjun, Guo Zhimin, Ji Yalu, Xi Hengyu, Wang Xinwu, Xue Yibing, Sun Changjiang, Feng Xin, Lei Liancheng, Tong Yigang, Liu Xiaoyun, Han Wenyu, Gu Jingmin
Abstract excerpt
Bacteriophage can be used as an alternative or complementary therapy to antibiotics for treating multidrug-resistant bacterial infections. However, the rapid emergence of resistant host variants during phage treatment has limited its therapeutic applications. In this study, a potential phage-resistant mechanism of Klebsiella pneumoniae was revealed. After phage GH-K3 treatment, a smooth-type colony, named K7RB,...
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