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The Mutation in wbaP cps Gene Cluster Selected by Phage-Borne Depolymerase Abolishes Capsule Production and Diminishes the Virulence of Klebsiella pneumoniae.

International journal of molecular sciences - 26 Oct 2021

Kaszowska Marta, Majkowska-Skrobek Grazyna, Markwitz Pawel, Lood Cédric, Jachymek Wojciech, Maciejewska Anna, Lukasiewicz Jolanta, Drulis-Kawa Zuzanna

Abstract excerpt

Klebsiella pneumoniae is considered one of the most critical multidrug-resistant pathogens and urgently requires new therapeutic strategies. Capsular polysaccharides (CPS), lipopolysaccharides (LPS), and exopolysaccharides (EPS) are the major virulence factors protecting K. pneumoniae against the immune response and thus may be targeted by phage-based therapeutics such as polysaccharides-degrading enzymes. Since...

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Identifiers

PMID: 34768992
DOI: 10.3390/ijms222111562
PMCID: PMC8583740

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Source receipt: pubmed, retrieved 7 Sept 2026.

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