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Article

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

2 Feb 2016

Abstract excerpt

Essential metals, such as iron and copper, play a critical role in a plethora of cellular processes including cell growth and proliferation. However, concomitantly, excess of these metal ions in the body can have deleterious effects due to their ability to generate cytotoxic reactive oxygen species (ROS). Thus, the human body has evolved a very well-orchestrated metabolic system that keeps tight control on the...

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PMID: 26844773
DOI: 10.1016/j.bbamcr.2016.01.026

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