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Article

Reframing paucigranulocytic asthma through genetic endotyping: a hypothesis-generating focus on the 17q21 rs7216389 locus.

Current opinion in allergy and clinical immunology - 1 Aug 2026

Poto Remo, Chan Rory, Breda Daniela, Varricchi Gilda, Burastero Samuele E

Abstract excerpt

PURPOSE OF REVIEW: Non-T2 asthma is currently defined by missing parameters, such as low blood eosinophils and FeNO, rather than positively identifiable mechanistic features. This definition overlaps with paucigranulocytic asthma (PGA). However, T2-biomarkers fluctuate over time, especially during glucocorticoid therapy, leading to potential over-diagnosis of T2-low asthma. Advancing beyond traditional endotyping...

Topics

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Asthma
Chromosomes, Human, Pair 17
Cytokines
Desensitization, Immunologic
Eosinophils

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

Thymic Stromal Lymphopoietin

Source

Open in PubMed Open full text

Identifiers

PMID: 41885394
DOI: 10.1097/ACI.0000000000001145
PMCID: PMC13336588

Genes

TSLP
GSDMB
ORMDL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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