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Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained

17 Feb 2018

Abstract excerpt

The identification of the most appropriate marker to measure reservoir size has been a great challenge for the HIV field. Quantitative viral outgrowth assay (QVOA), the reference standard to quantify the amount of replication-competent virus, has several limitations, as it is laborious, expensive, and unable to robustly reactivate every single integrated provirus. PCR-based assays have been developed as an...

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PMID: 29452580
DOI: 10.1186/s12977-018-0396-3

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