Article
Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis.
Science translational medicine - 27 Apr 2022
Lefrancq Noémie, Bouchez Valérie, Fernandes Nadia, Barkoff Alex-Mikael, Bosch Thijs, Dalby Tine, Åkerlund Thomas, Darenberg Jessica, Fabianova Katerina, Vestrheim Didrik F, Fry Norman K, González-López Juan José, Gullsby Karolina, Habington Adele, He Qiushui, Litt David, Martini Helena, Piérard Denis, Stefanelli Paola, Stegger Marc, Zavadilova Jana, Armatys Nathalie, Landier Annie, Guillot Sophie, Hong Samuel L, Lemey Philippe, Parkhill Julian, Toubiana Julie, Cauchemez Simon, Salje Henrik, Brisse Sylvain
Abstract excerpt
As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.