Article

Genomic Surveillance Reveals Global Spread of Macrolide-Resistant <i>Bordetella pertussis</i> Linked to Vaccine Changes

2025-07-16

Abstract excerpt

The resurgence of whooping cough in regions utilizing acellular pertussis vaccines underscopes emerging public health challenges. Here, we characterized 178 Bordetella pertussis isolates collected from patients across all age groups in Shanghai (2018-2024) to assess genomic evolution and antibiotic susceptibility. Macrolide resistance to erythromycin, azithromycin, clarithromycin and clindamycin escalated from ≤5...

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Literature Corpus work: 8dc433cf-93f5-58a0-ba1e-c33d103dc8a0
DOI: 10.1101/2025.07.16.665123

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