Article
Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.
Scientific reports - 18 Aug 2015
Xu Yinghua, Liu Bin, Gröndahl-Yli-Hannuksila Kirsi, Tan Yajun, Feng Lu, Kallonen Teemu, Wang Lichan, Peng Ding, He Qiushui, Wang Lei, Zhang Shumin
Abstract excerpt
Herd immunity can potentially induce a change of circulating viruses. However, it remains largely unknown that how bacterial pathogens adapt to vaccination. In this study, Bordetella pertussis, the causative agent of whooping cough, was selected as an example to explore possible effect of vaccination on the bacterial pathogen. We sequenced and analysed the complete genomes of 40 B. pertussis strains from Finland...
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