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Article

Genomic surveillance reveals global spread of macrolide-resistant Bordetella pertussis linked to vaccine changes.

Journal of clinical microbiology - 17 Dec 2025

Xu Zhen, Huang Zhuoying, Yuan Lingyue, Wu Huanyu, Chen Xin, Chen Min, Zhuang Yuan, Feng Jun

Abstract excerpt

The resurgence of whooping cough in regions utilizing acellular pertussis vaccines underscores emerging public health challenges. Here, we characterized 178 Bordetella pertussis isolates collected from patients across all age groups in Shanghai (2018-2024) to assess genomic evolution and antibiotic susceptibility. Macrolide resistance to erythromycin, azithromycin, and clarithromycin escalated from ≤50%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41236009
DOI: 10.1128/jcm.01064-25
PMCID: PMC12710321

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