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Article

Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2023

Wong Yvette C, Jayaraj Nirupa D, Belton Tayler B, Shum George C, Ball Hannah E, Ren Dongjun, Tadenev Abigail L D, Krainc Dimitri, Burgess Robert W, Menichella Daniela M

Abstract excerpt

Inter-organelle contact sites between mitochondria and lysosomes mediate the crosstalk and bidirectional regulation of their dynamics in health and disease. However, mitochondria-lysosome contact sites and their misregulation have not been investigated in peripheral sensory neurons. Charcot-Marie-Tooth type 2B disease is an autosomal dominant axonal neuropathy affecting peripheral sensory neurons caused by...

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PMID: 37878717
DOI: 10.1073/pnas.2313010120
PMCID: PMC10622892

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