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Distinct Potentially Adaptive Accumulation of Truncation Mutations in Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi A.

Microbiology spectrum - 29 Jun 2022

Robinson Stephy Mol, Rajachandran Vyshakh, Majumdar Suchismita, Saha Satabdi, Das Sneha, Chattopadhyay Sujay

Abstract excerpt

Gene inactivation through the accumulation of truncation (or premature stop codon) mutations is a common mode of evolution in bacteria. It is frequently believed to result from reductive evolutionary processes allowing purging of superfluous traits. However, several works have demonstrated that, similar to the occurrences of inactivating nonsynonymous (i.e., amino acid replacement) mutations under positive...

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PMID: 35467366
DOI: 10.1128/spectrum.01969-21
PMCID: PMC9241588

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