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Article

Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi.

PLoS pathogens - 1 Oct 2020

Thanh Duy Pham, Thieu Nga Tran Vu, Nguyen Thi Nguyen To, Ngoc Dan Thanh Ho, Dongol Sabina, Karkey Abhilasha, Carey Megan, Basnyat Buddha, Dougan Gordon, Rabaa Maia A, Baker Stephen

Abstract excerpt

Despite recent advances in typhoid fever control, asymptomatic carriage of Salmonella Typhi in the gallbladder remains poorly understood. Aiming to understand if S. Typhi becomes genetically adapted for long-term colonisation in the gallbladder, we performed whole genome sequencing on a collection of S. Typhi isolated from the gallbladders of typhoid carriers. These sequences were compared to contemporaneously...

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Source

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Identifiers

PMID: 33085725
DOI: 10.1371/journal.ppat.1008998
PMCID: PMC7605710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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