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Article

High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi.

Nature genetics - 1 Aug 2008

Holt Kathryn E, Parkhill Julian, Mazzoni Camila J, Roumagnac Philippe, Weill François-Xavier, Goodhead Ian, Rance Richard, Baker Stephen, Maskell Duncan J, Wain John, Dolecek Christiane, Achtman Mark, Dougan Gordon

Abstract excerpt

Isolates of Salmonella enterica serovar Typhi (Typhi), a human-restricted bacterial pathogen that causes typhoid, show limited genetic variation. We generated whole-genome sequences for 19 Typhi isolates using 454 (Roche) and Solexa (Illumina) technologies. Isolates, including the previously sequenced CT18 and Ty2 isolates, were selected to represent major nodes in the phylogenetic tree. Comparative analysis...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18660809
DOI: 10.1038/ng.195
PMCID: PMC2652037

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Source receipt: pubmed, retrieved 7 Sept 2026.

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