Article

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to <i>Salmonella</i> Typhi

2024-01-03

Abstract excerpt

Many bacterial pathogens, including the human exclusive pathogen Salmonella Typhi, express capsular polysaccharides as a crucial virulence factor. Here, through S. Typhi whole genome sequence analyses and functional studies, we found a list of single point mutations that make S . Typhi hypervirulent. We discovered a single point mutation in the Vi biosynthesis enzymes that control the length or acetylation of V...

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Literature Corpus work: 6b49490e-969f-5dff-ba2d-9f48ee228a21
DOI: 10.1101/2023.12.28.573590

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