Antibacterial and Cytotoxic Actinomycins Y6–Y9 and Zp from Streptomyces sp. Strain Gö-GS12

Abstract excerpt

Four new Y-type actinomycin analogues named Y 6 –Y 9 ( 1 – 4 ) were isolated and characterized from the scale-up fermentation of the Streptomyces sp. strain Gö-GS12, as well as actinomycin Zp ( 5 ), which was, for the first time, isolated as a natural product. Structures of the new compounds were elucidated by the cumulative analyses of NMR spectroscopy and HRMS. The 4-hydroxythreonine on the β-ring of 1 uniquely...

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