Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences

Abstract excerpt

Novel antibiotics are urgently needed to address the looming global crisis of antibiotic resistance. Historically, the primary source of clinically used antibiotics has been microbial secondary metabolism. Microbial genome sequencing has revealed a plethora of uncharacterized natural antibiotics that remain to be discovered. However, the isolation of these molecules is hindered by the challenge of linking...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computational Drug Discovery Methods
• Share to Genomics and Phylogenetic Studies
• Share to Microbial Natural Products and Biosynthesis