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Article

Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches.

American journal of human genetics - 5 May 2022

Zuber Verena, Grinberg Nastasiya F, Gill Dipender, Manipur Ichcha, Slob Eric A W, Patel Ashish, Wallace Chris, Burgess Stephen

Abstract excerpt

Mendelian randomization and colocalization are two statistical approaches that can be applied to summarized data from genome-wide association studies (GWASs) to understand relationships between traits and diseases. However, despite similarities in scope, they are different in their objectives, implementation, and interpretation, in part because they were developed to serve different scientific communities....

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PMID: 35452592
DOI: 10.1016/j.ajhg.2022.04.001
PMCID: PMC7612737

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