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Article

A Polynesian-specific copy number variant encompassing the MICA gene associates with gout.

Human molecular genetics - 28 Oct 2022

Wang Ke, Cadzow Murray, Bixley Matt, Leask Megan P, Merriman Marilyn E, Yang Qiangzhen, Li Zhiqiang, Takei Riku, Phipps-Green Amanda, Major Tanya J, Topless Ruth, Dalbeth Nicola, King Frances, Murphy Rinki, Stamp Lisa K, de Zoysa Janak, Wang Zhuo, Shi Yongyong, Merriman Tony R

Abstract excerpt

Gout is of particularly high prevalence in the Māori and Pacific (Polynesian) populations of Aotearoa New Zealand (NZ). Here, we investigated the contribution of common population-specific copy number variation (CNV) to gout in the Aotearoa NZ Polynesian population. Microarray-generated genome-wide genotype data from Aotearoa NZ Polynesian individuals with (n = 1196) and without (n = 1249) gout were analyzed....

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Identifiers

PMID: 35451026
DOI: 10.1093/hmg/ddac094
PMCID: PMC9616569

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